Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial

摘要: Abstract Objective This study was conducted to determine the effects of long-term folate supplementation on regression and metabolic status patients with cervical intraepithelial neoplasia grade 1 (CIN1). Methods randomized, double-blind, placebo-controlled trial performed among 58 women diagnosed CIN1, ages 18 55 y old. Participants were randomly divided into two groups receive 5 mg/d supplements (n = 29) or placebo for 6 mo. Fasting blood samples taken at baseline 6 mo after intervention quantify related markers. Results A greater percentage in group had regressed CIN1 (83.3 versus 52.0%, P  = 0.019) than those group. Long-term resulted a significant decrease serum insulin levels (−1.6 ± 6.2 +2.6 ± 6.9 μIU/mL,  = 0.018) homeostatic model assessment-beta cell function (HOMA-B) (−13.0 ± 39.0 +11.2 ± 42.3,  = 0.028) compared placebo. Additionally, plasma glutathione (GSH) significantly increased (+81.5 ± 264.1 −220.9 ± 342.5 μmol/L,  = 0.004) Conclusions Taken together, (5 mg/d) its as well led decreased insulin, HOMA-B, MDA GSH levels; however, it did not affect other profiles.