Optical spectroscopy to diagnose Alzheimer's disease in vivo

作者: Eugene B. Hanlon , Donald F. Siwek , Ann C. Mckee , Neil W. Kowall , Hui Fang

DOI: 10.1364/BIO.2004.WC1

关键词: PathologyLight propagationParticle scatteringMaterials scienceMie scatteringIn vivoSpectroscopyDiffuse reflectionProtein aggregationLight scatteringNuclear magnetic resonance

摘要: Neurodegenerative pathologies such as Alzheimer's disease present protein aggregates that scatter light. We are developing techniques to detect their characteristic spectra in vivo a basis for definitive, non-invasive diagnosis and monitoring experimental therapeutics.

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