Radiation dosimetry estimates of 18F-alfatide II based on whole-body PET imaging of mice
作者： Si-yang Wang , Xiao Bao , Ming-wei Wang , Yong-ping Zhang , Ying-jian Zhang
DOI: 10.1016/J.APRADISO.2015.07.013
关键词: Effective dose (radiation) 、 18F-Alfatide II 、 Radiology 、 Whole body imaging 、 Tail vein 、 Positron emission tomography 、 Biodistribution 、 Dosimetry 、 Whole body pet 、 Medicine 、 Nuclear medicine
摘要: We estimated the dosimetry of (18)F-alfatide II with method established by MIRD based on biodistribution data mice. Six mice (three females and three males) were scanned for 160min an Inveon MicroPET/CT scanner after injection via tail vein. Eight source organs delineated CT images their residence times calculated. The was then converted to human using scaling factors organ body weight. absorbed doses resulting effective dose computed OLINDA 1.1 software. highest observed in urinary bladder wall (male 0.102mGy/MBq, female 0.147mGy/MBq); lowest one detected brain 0.0030mGy/MBq, 0.0036). total 0.0127mSv/MBq male 0.0166 mSv/MBq female, respectively. A 370-MBq led 4.70mSv 6.14mSv female. potential radiation burden associated II/PET imaging therefore is comparable other PET examinations.
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sci-hub.se 参考文章(18)
K. Van Laere, M. Koole, S. M. Sanabria Bohorquez, K. Goffin, I. Guenther, M. J. Belanger, J. Cote, P. Rothenberg, I. De Lepeleire, I. D. Grachev, R. J. Hargreaves, G. Bormans, H. D. Burns, Whole-Body Biodistribution and Radiation Dosimetry of the Human Cannabinoid Type-1 Receptor Ligand 18F-MK-9470 in Healthy Subjects The Journal of Nuclear Medicine. ,vol. 49, pp. 439- 445 ,(2008) , 10.2967/JNUMED.107.047290
Jinxia Guo, Lixin Lang, Shuo Hu, Ning Guo, Lei Zhu, Zhongchan Sun, Ying Ma, Dale O. Kiesewetter, Gang Niu, Qingguo Xie, Xiaoyuan Chen, Comparison of Three Dimeric 18F-AlF-NOTA-RGD Tracers Molecular Imaging and Biology. ,vol. 16, pp. 274- 283 ,(2014) , 10.1007/S11307-013-0668-1
Jordan D. Verschuer, Jocelyn Towson, Stefan Eberl, Andrew Katsifis, David Henderson, Peter Lam, Lingfeng Wen, Christian Loc'h, Filomena Mattner, Sally Thomson, Armin Mohamed, Michael J. Fulham, Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102. Nuclear Medicine and Biology. ,vol. 39, pp. 742- 753 ,(2012) , 10.1016/J.NUCMEDBIO.2011.11.003
Orit Jacobson, Lei Zhu, Ying Ma, Ido D. Weiss, Xilin Sun, Gang Niu, Dale O. Kiesewetter, Xiaoyuan Chen, Rapid and Simple One-Step F-18 Labeling of Peptides Bioconjugate Chemistry. ,vol. 22, pp. 422- 428 ,(2011) , 10.1021/BC100437Q
Mitra Ahmadi, Lucie Sancey, Arnaud Briat, Laurent Riou, Didier Boturyn, Pascal Dumy, Daniel Fagret, Catherine Ghezzi, Jean-Philippe Vuillez, Chemical and biological evaluations of an (111)in-labeled RGD-peptide targeting integrin alpha(V) beta(3) in a preclinical tumor model. Cancer Biotherapy and Radiopharmaceuticals. ,vol. 23, pp. 691- 700 ,(2008) , 10.1089/CBR.2008.0528
X CHEN, S LIU, Y HOU, M TOHME, R PARK, J BADING, P CONTI, MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides. Molecular Imaging and Biology. ,vol. 6, pp. 350- 359 ,(2004) , 10.1016/J.MIBIO.2004.06.004
Kazuhiro Kitajima, Koji Murakami, Erena Yamasaki, Yasushi Domeki, Yasushi Kaji, Ichio Fukasawa, Noriyuki Inaba, Narufumi Suganuma, Kazuro Sugimura, Performance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: Comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CT. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 36, pp. 1388- 1396 ,(2008) , 10.1007/S00259-008-0776-3
S.M. Moerlein, J.S. Perlmutter, P.D. Cutler, M.J. Welch, Radiation dosimetry of [18F](N-methyl)benperidol as determined by whole-body PET imaging of primates Nuclear Medicine and Biology. ,vol. 24, pp. 311- 318 ,(1997) , 10.1016/S0969-8051(97)00042-5
Cristian C. Constantinescu, Evgueni Sevrioukov, Adriana Garcia, Min-Liang Pan, Jogeshwar Mukherjee, Evaluation of [18F]Mefway biodistribution and dosimetry based on whole-body PET imaging of mice. Molecular Imaging and Biology. ,vol. 15, pp. 222- 229 ,(2013) , 10.1007/S11307-012-0582-Y
Cristian C. Constantinescu, Adriana Garcia, M. Reza Mirbolooki, Min-Liang Pan, Jogeshwar Mukherjee, Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice. Nuclear Medicine and Biology. ,vol. 40, pp. 289- 294 ,(2013) , 10.1016/J.NUCMEDBIO.2012.11.004