Animal models to look for polygenic effects in cancer predisposition

作者: T. A. Dragani , M. A. Pierotti

DOI: 10.1007/978-94-011-0677-1_7

关键词: PopulationAlleleInbred strainGenetic predispositionGeneticsPhylogenetic treeBiologyCancer predisposition

摘要: Most inbred strains of laboratory rodents derive from the wild Mus musculus and domesticus that were trapped at beginning century. Although some intermixing between has occurred, stains are derived one other, phylogenetic analysis shown differ genetically each other1. Therefore, may be a sufficiently wide representation distribution frequency different alleles, including those related to cancer predisposition, wild-type murine population which they derived.

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