Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule
作者： Emilien folzer , Katharina diepold , Katrin bomans , Christof finkler , Roland schmidt
DOI: 10.1002/JPS.24509
关键词: Forced degradation 、 Reagent 、 Tryptophan 、 Biological activity 、 Chemistry 、 Amino acid 、 Hydrogen peroxide 、 Biochemistry 、 Protein oxidation 、 Methionine
摘要: … in the case of monoclonal antibodies (mAbs) where binding … that oxidation of methionine from the Fc region can reduce … for the oxidation of a recombinant antibody performed with …
core.ac.uk
sci-hub.se 参考文章(33)
Daniel Steinmann, J. Andrea Ji, Y. John Wang, Christian Schöneich, Oxidation of human growth hormone by oxygen-centered radicals: formation of Leu-101 hydroperoxide and Tyr-103 oxidation products. Molecular Pharmaceutics. ,vol. 9, pp. 803- 814 ,(2012) , 10.1021/MP3001028
Rodney G. Keck, The Use of t-Butyl Hydroperoxide as a Probe for Methionine Oxidation in Proteins Analytical Biochemistry. ,vol. 236, pp. 56- 62 ,(1996) , 10.1006/ABIO.1996.0131
Rajesh Krishnamurthy, Rapti D. Madurawe, Kristen D. Bush, Janice A. Lumpkin, Conditions Promoting Metal‐Catalyzed Oxidations during Immobilized Cu—Iminodiacetic Acid Metal Affinity Chromatography Biotechnology Progress. ,vol. 11, pp. 643- 650 ,(1995) , 10.1021/BP00036A007
Quanzhou Luo, Marisa K. Joubert, Riki Stevenson, Randal R. Ketchem, Linda O. Narhi, Jette Wypych, Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions Journal of Biological Chemistry. ,vol. 286, pp. 25134- 25144 ,(2011) , 10.1074/JBC.M110.160440
Tilman Schlothauer, Petra Rueger, Jan Olaf Stracke, Hubert Hertenberger, Felix Fingas, Lothar Kling, Thomas Emrich, Georg Drabner, Stefan Seeber, Johannes Auer, Stefan Koch, Apollon Papadimitriou, Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies mAbs. ,vol. 5, pp. 576- 586 ,(2013) , 10.4161/MABS.24981
Jay Werber, Y. John Wang, Michael Milligan, Xiaohua Li, Junyan A. Ji, Analysis of 2,2’-Azobis (2-Amidinopropane) Dihydrochloride Degradation and Hydrolysis in Aqueous Solutions Journal of Pharmaceutical Sciences. ,vol. 100, pp. 3307- 3315 ,(2011) , 10.1002/JPS.22578
Walter R. Wasylaschuk, Paul A. Harmon, Gabriella Wagner, Amy B. Harman, Allen C. Templeton, Hui Xu, Robert A. Reed, Evaluation of hydroperoxides in common pharmaceutical excipients Journal of Pharmaceutical Sciences. ,vol. 96, pp. 106- 116 ,(2007) , 10.1002/JPS.20726
Markus Haberger, Katrin Bomans, Katharina Diepold, Michaela Hook, Jana Gassner, Tilman Schlothauer, Adrian Zwick, Christian Spick, Jochen Felix Kepert, Brigitte Hienz, Michael Wiedmann, Hermann Beck, Philipp Metzger, Michael Mølhøj, Constanze Knoblich, Ulla Grauschopf, Dietmar Reusch, Patrick Bulau, Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes mAbs. ,vol. 6, pp. 327- 339 ,(2014) , 10.4161/MABS.27876
Riccardo Torosantucci, Christian Schöneich, Wim Jiskoot, Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences Pharmaceutical Research. ,vol. 31, pp. 541- 553 ,(2014) , 10.1007/S11095-013-1199-9
Pei Qi, David B. Volkin, Hui Zhao, Michael L. Nedved, Robert Hughes, Ryan Bass, Sun C. Yi, Mark E. Panek, Dana Wang, Paul DalMonte, Michael D. Bond, Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form. Journal of Pharmaceutical Sciences. ,vol. 98, pp. 3117- 3130 ,(2009) , 10.1002/JPS.21617