Modelling inhaled particle deposition in the human lung—A review

摘要: Abstract Particle deposition in the human respiratory tract is determined by biological factors such as lung morphology and breathing patterns, physical fluid dynamics, particle properties, mechanisms. Current models may be grouped into two categories referring to region of interest lung, i.e. either whole (whole models), or a localized (local scale models). In models, individual airways computed analytical equations for efficiencies specific flow conditions (analytical The present review focuses upon philosophy different conceptual determine bronchial acinar airway generations, compare patterns predicted these models. Since any modelling approach requires validation comparison with available experimental evidence, data are compared published subjects. This indicates that, at least during writing this review, can validated only total and, some extent, regional deposition. local transport solved Computational Fluid Dynamics (CFPD) methods (numerical providing information on within selected structural elements e.g. bifurcations. however, their potential contribution improve current will considered.