Vascular calcification and disordered mineral metabolism in dialysis patients.

摘要: Vascular calcification is an active, cell-mediated process that can involve either the intima or media of blood vessels. The current methods used to clinically measure vascular cannot distinguish between intimal (invariably atherosclerotic) and medial calcification. high scores seen in patients with end-stage renal disease likely represent a composite burden both sites. severity has been associated variety findings including left ventricular hypertrophy angiographic stenosis as well all-cause cardiovascular mortality. There increasing evidence disordered mineral metabolism participates one mechanisms whereby hyperphosphatemia, hypercalcemia, hyperparathyroidism enhance mortality patients. are no studies showing improved outcomes ESRD aggressive control metabolism. However, preponderance argues strongly favor management these abnormalities from starting early course chronic kidney hope improving patient outcomes.