A dual-inhibitor system for the effective antifibrillation of Aβ40 peptides by biodegradable EGCG-Fe(iii)/PVP nanoparticles.
作者： Zexiu Liu , Xianglong Li , Xiaoping Wu , Chunling Zhu
DOI: 10.1039/C8TB03266A
关键词: Biocompatibility 、 Chemical engineering 、 Nanoparticle 、 Chemistry 、 Antioxidant 、 Simulated body fluid 、 Biodegradation 、 Dual inhibitor 、 Inhibitory effect 、 Penetration (firestop)
摘要: Recently, due to their properties of high surface-to-volume ratio, easy penetration the blood-brain barrier and easily modified surfaces, nanoparticles (NPs) have been recognized as promising inhibitors for Alzheimer's disease (AD) diagnosis therapy. However, achieve clinical application, design synthesis specific NPs with good biocompatibility degradability still are main focus research. In this paper, EGCG-Fe(iii)/PVP (EFPP) ultra-small size were first fabricated by coordination reaction between Fe3+, EGCG PVP. The obtained EFPP exhibited effective influence on inhibition Aβ40 fibrillation disaggregation existing fibrils. inhibitory effect was mainly derived from synergistic weak hydrophobicity PVP antioxidant activity EGCG. With advantages synthesis, stability in simulated body fluid, performance towards antifibrillation biodegradability, it is reasonable consider that as-prepared application prospects treatment AD.
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