Drug-Loadable Calcium Alginate Hydrogel System for Use in Oral Bone Tissue Repair.
作者： Luyuan Chen , Renze Shen , Satoshi Komasa , Yanxiang Xue , Bingyu Jin
DOI: 10.3390/IJMS18050989
关键词: Chemistry 、 Polylactic acid 、 Biomedical engineering 、 Calcium alginate 、 Bone tissue 、 Bone marrow 、 Biocompatibility 、 Stromal cell 、 Periodontal fiber 、 Self-healing hydrogels 、 Anatomy
摘要: This study developed a drug-loadable hydrogel system with high plasticity and favorable biological properties to enhance oral bone tissue regeneration. Hydrogels of different calcium alginate concentrations were prepared. Their swelling ratio, degradation time, bovine serum albumin (BSA) release rate measured. Human periodontal ligament cells (hPDLCs) marrow stromal (BMSCs) cultured both hydrogels polylactic acid (PLA), then we examined the proliferation cells. Inflammatory-related factor gene expressions hPDLCs osteogenesis-related BMSCs observed. Materials implanted into subcutaneous rabbits determine biosecurity materials. The materials also in mandibular defects scanned using micro-CT. caused less inflammation than PLA. number mineralized nodules expression osteoblast-related genes significantly higher group compared control group. When tissue, showed biocompatibility. had superior osteoinductive ability is potential defect reparation material for clinical dental application.
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