A study of polar lipid drug systems undergoing a thermoreversible lamellar-to-cubic phase transition

摘要: Abstract The polar insoluble, but swelling, lipid monoolein (glyceryl monooleate) forms a highly ordered cubic phase in excess water, which can be used to sustain the release of different types drugs. One problem with phase, however, is its stiffness, and order make administration easier, precursors form lamellar were investigated. This undergoes transition on temperature increase; thus system formed this way acts similar situ activated gel-forming polymer systems, e.g., Pluronic D-127, Gelrite EHEC. Lipid drug carrier systems made from wide variety lipids. They also application drugs, are very versatile as regards site administration. can, therefore, an interesting alternative systems.