Quantifying mechanical force in axonal growth and guidance.

摘要: Mechanical force plays a fundamental role in neuronal development, physiology, and regeneration. In particular, research has shown that is involved growth cone-mediated axonal guidance as well stretch-induced elongation when an organism increases size after forming initial synaptic connections. However, much of the details about exact these processes remain unknown. this review, we highlight: (1) standing questions concerning mechanical guidance; (2) different experimental techniques used to quantify forces axons cones. We believe satisfying answers will require quantitative information relationship between elongation, forces, cytoskeletal dynamics, transport, signaling, substrate adhesion, stiffness contributing directional advance. Furthermore, address why wide range values have been reported literature, what mean context mechanics. hope review provide guide for those interested studying development regeneration networks.