From Cyclopentadiene to Isoxazoline‐Carbocyclic Nucleosides; Synthesis of Highly Active Inhibitors of Influenza A Virus H1N1
作者： Paolo Quadrelli , Mariella Mella , Laura Legnani , Dalya Al-Saad
关键词: Cyclopentadiene 、 Influenza A virus 、 Quinoline 、 Stereochemistry 、 Nucleoside 、 Chemistry 、 Moiety 、 Purine 、 Cycloaddition 、 Virus
摘要: The synthesis of isoxazolino-carbocyclic nornucleosides incorporating a quinoline moiety was tuned through nitrosocarbonyl intermediate chemistry, and range adenine analogues were attained the linear construction purine heterocyclic rings. hinges on exo-selective 1,3-dipolar cycloaddition quinolinenitrile oxide to 2,3-oxazanorborn-5-enes simple elaboration cycloadducts. nucleoside derivatives initially tested for their inhibitory activity against variety viruses, including HBV, PTV Flu A virus H1N1. High antiviral activities found compounds 22aA 22bA in case
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