Pyridinium N-2′-pyridylaminide: radical cyclization for the synthesis of benzonaphthyridine derivatives

作者: Araceli Núñez , Aránzazu Sánchez , Carolina Burgos , Julio Alvarez-Builla

DOI: 10.1016/J.TET.2007.04.077

关键词: Radical cyclizationPyridiniumChemical structureChemical modificationChemical reactionChemistryOrganic chemistryBiochemistryDrug discovery

摘要: Financial support from the CICYT (project CTQ2005- 08902/BQU) and two grants Universidad de Alcala (A.S) Ministerio Educacion y Ciencia (Spain) (A.N.) are gratefully acknowledged.

参考文章(35)
Valentín Martínez-Barrasa, Aránzazu García de Viedma, Carolina Burgos, Julio Alvarez-Builla, Synthesis of biaryls via intermolecular radical addition of heteroaryl and aryl bromides onto arenes Organic Letters. ,vol. 2, pp. 3933- 3935 ,(2000) , 10.1021/OL006722C
Hongbin Li, Jeffrey L. Petersen, Kung K. Wang, Cascade cyclizations via N,4-didehydro-2-(phenylamino)pyridine biradicals/zwitterions generated from enyne-carbodiimides. Journal of Organic Chemistry. ,vol. 68, pp. 5512- 5518 ,(2003) , 10.1021/JO020760N
Shunji Aoki, Dexin Kong, Hideaki Suna, Yoshihiro Sowa, Toshiyuki Sakai, Andi Setiawan, Motomasa Kobayashi, Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner. Biochemical and Biophysical Research Communications. ,vol. 342, pp. 101- 106 ,(2006) , 10.1016/J.BBRC.2006.01.119
Rebeca de la Rosa, Valentı́n Martı́nez-Barrasa, Carolina Burgos, Julio Alvarez-Builla, N-Azinylpyridinium N-aminides: tandem reactions with α-halocarbonyl derivatives and analogs Tetrahedron Letters. ,vol. 41, pp. 5837- 5840 ,(2000) , 10.1016/S0040-4039(00)00839-X
Sheow-Fong Wang, Che-Ping Chuang, Jia-Han Lee, Shui-Te Liu, Sodium p-toluenesulfinate/copper(II) acetate in free radical reactions of 5-aryl substituted alkenes Tetrahedron. ,vol. 55, pp. 2273- 2288 ,(1999) , 10.1016/S0040-4020(99)00027-7
A.K. Ganguly, C.H. Wang, T.M. Chan, Y.H. Ing, A.V. Buevich, Synthesis of heterocyclic compounds using radical reactions and evidence for the formation of spiro radical intermediates Tetrahedron Letters. ,vol. 45, pp. 883- 886 ,(2004) , 10.1016/J.TETLET.2003.10.204
Thomas Cailly, Frédéric Fabis, Sylvain Rault, A new, direct, and efficient synthesis of benzonaphthyridin-5-ones Tetrahedron. ,vol. 62, pp. 5862- 5867 ,(2006) , 10.1016/J.TET.2006.04.030
Alexis D. C. Parenty, Louise V. Smith, Kevin M. Guthrie, De-Liang Long, Jane Plumb, Robert Brown, Leroy Cronin, Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties. Journal of Medicinal Chemistry. ,vol. 48, pp. 4504- 4506 ,(2005) , 10.1021/JM050320Z
Aránzazu García de Viedma, Valentín Martínez-Barrasa, Carolina Burgos, M. Luisa Izquierdo, Julio Alvarez-Builla, N-Azinylpyridinium N-Aminides: Intermediates for the Regioselective Synthesis of 3-Fluoro-2-aminopyridine Derivatives Journal of Organic Chemistry. ,vol. 64, pp. 1007- 1010 ,(1999) , 10.1021/JO9813540