Pulsed dye laser vs. photodynamic therapy in the treatment of refractory nail psoriasis: a comparative pilot study
作者： M Fernández-Guarino , A Harto , M Sánchez-Ronco , I García-Morales , P Jaén
DOI: 10.1111/J.1468-3083.2009.03196.X
关键词: Refractory 、 Nail psoriasis 、 Photodynamic therapy 、 Nail matrix 、 Nail (anatomy) 、 Psoriasis 、 Medicine 、 Light source 、 Dermatology 、 Subjective impression 、 Surgery
摘要: Abstract Background Nail psoriasis is often refractory to traditional treatments, and patients with nail usually demand a therapeutic option. Both photodynamic therapy (PDT) pulse dye laser (PDL) have proved effective for plaque-type psoriasis, but they not been evaluated in psoriasis. On the other hand, delta-aminolaevulinic acic has shown penetrate into matrix bed occluded bioadhesive patches. Objectives To compare efficacy of PDT PDL treatment psoriasis Methods We studied 61 nails treated 60 group 14 patients. The used as light source. Sessions were applied monthly treating one hand PDL. was methyl-aminolaevulinic (MAL, Metvix®) 3 h using patch. at baseline, after 6 months according Psoriasis Severity Index (NAPSI) score. Results A decrease NAPSI score observed both treatments involvement. No statistical differences found between (P = 0.632, P = 0.084, P = 0.535, months, respectively), scores (P = 0.423 P = 0.853, respectively). subjective impression good, especially regarding pain. Conclusions seems be improves MAL does seem play role clinical response. Conflicts interest None declared.
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