Characterization and identification of microRNA core promoters in four model species

摘要: MicroRNAs are short, noncoding RNAs that play important roles in post-transcriptional gene regulation. Although many functions of microRNAs plants and animals have been revealed recent years, the transcriptional mechanism microRNA genes is not well-understood. To elucidate regulation genes, we study characterize, a genome scale, promoters intergenic Caenorhabditis elegans, Homo sapiens, Arabidopsis thaliana, Oryza sativa. We show most known these four species same type as protein-coding have. further characterize developed novel promoter prediction method, called common query voting (CoVote), which more effective than available methods. Using this new identify putative core model species. Moreover, discover significant, characteristic sequence motifs promoters, several match or resemble cis-acting elements for transcription initiation. Among motifs, some conserved across different while specific to individual