Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice.
作者： Sung Phil Kim , Mi Young Kang , Jae Ho Kim , Seok Hyun Nam , Mendel Friedman
DOI: 10.1021/JF201944N
关键词: Hot water extraction 、 Phagocytosis 、 Pharmacology 、 Hericium erinaceus 、 Gas chromatography–mass spectrometry 、 Nitric oxide 、 Immunology 、 Mushroom 、 Ethanol 、 Bioassay 、 Chemistry
摘要: We investigated antitumor effects of the following four extracts freeze-dried Hericium erinaceus mushrooms in Balb/c mice intracutaneously transplanted on backs with CT-26 colon cancer cells: HWE, hot water extraction by boiling for 3 h; MWE, microwaving 50% ethanol/water at 60 W min; and ACE AKE, 1% HCl or 3% NaOH 2 h. HWE MWE a higher content β-glucans, determined an assay kit, than MKE were active all bioassays. Gas chromatography/mass spectrometry analyses showed presence 40, 27, 16, 13 compounds, respectively, extracts. Daily intraperitoneal (ip) injections weeks significantly reduced tumor weights 38 41%. Tumor regressions associated changes biomarkers as compared to phosphate buffer (PBS)-treated control mice: 2.7- 2.4-fold increases cytolytic activity splenic natural killer (NK) cells; restored nitric oxide production phagocytosis ...
acs.org
sci-hub.se 参考文章(30)
Rui-Hua Shi, Jian Wu, Yun Bao, Jian-Guo Yang, Xue-Hao Wang, Jian-Dong Tong, Zhi-Gang Yan, Xiao-Yu Li, Guo-Xin Zhang, Yan-Bing Ding, Wei-Ming Xiao, PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. Experimental Oncology. ,vol. 27, pp. 108- ,(2005)
Ching-Hua Su, Jinn-Chyi Wang, Shu-Hui Hu, Tsong-Ming Lee, Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. Kaohsiung Journal of Medical Sciences. ,vol. 17, pp. 461- 467 ,(2001) , 10.6452/KJMS.200109.0461
S Narumi, J H Finke, T A Hamilton, Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages. Journal of Biological Chemistry. ,vol. 265, pp. 7036- 7041 ,(1990) , 10.1016/S0021-9258(19)39255-5
Carol J. Burger, David W. Mullins, Klaus D. Elgert, Paclitaxel enhances macrophage IL-12 production in tumor-bearing hosts through nitric oxide. Journal of Immunology. ,vol. 162, pp. 6811- 6818 ,(1999)
Andrea T. Borchers, Carl L. Keen, M. Eric Gershwin, Mushrooms, tumors, and immunity: an update. Experimental Biology and Medicine. ,vol. 229, pp. 393- 406 ,(2004) , 10.1177/153537020422900507
Zhang Yu, Gu Ming, Wang Kaiping, Chen Zhixiang, Dai Liquan, Liu Jingyu, Zeng Fang, Structure, chain conformation and antitumor activity of a novel polysaccharide from Lentinus edodes. Fitoterapia. ,vol. 81, pp. 1163- 1170 ,(2010) , 10.1016/J.FITOTE.2010.07.019
Jessica A. Bertout, Shetal A. Patel, M. Celeste Simon, The impact of O2 availability on human cancer Nature Reviews Cancer. ,vol. 8, pp. 967- 975 ,(2008) , 10.1038/NRC2540
Hui-Hsin Chang, Kuang-Yang Hsieh, Chen-Hao Yeh, Yuan-Ping Tu, Fuu Sheu, Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma International Immunopharmacology. ,vol. 10, pp. 239- 246 ,(2010) , 10.1016/J.INTIMP.2009.10.017
Kyung-Hee Sohn, Ho-Young Lee, Hae-Young Chung, Han-Suk Young, Seh-Yoon Yi, Kyu-Won Kim, Anti-angiogenic activity of triterpene acids Cancer Letters. ,vol. 94, pp. 213- 218 ,(1995) , 10.1016/0304-3835(95)03856-R
Jong-Suk Lee, Byung Chul Park, Yu Jin Ko, Mi Kyoung Choi, Han Gon Choi, Chul Soon Yong, Jae-Sung Lee, Jung-Ae Kim, None, Grifola frondosa (maitake mushroom) water extract inhibits vascular endothelial growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase phosphorylation. Journal of Medicinal Food. ,vol. 11, pp. 643- 651 ,(2008) , 10.1089/JMF.2007.0629