Genome-wide association study for milking speed in French Holstein cows
作者： Andrew Marete , Goutam Sahana , Sébastien Fritz , Rachel Lefebvre , Anne Barbat
关键词: SNP 、 Mastitis 、 SNP array 、 Genome-wide association study 、 Milking 、 Biology 、 Single-nucleotide polymorphism 、 Genetic association 、 Quantitative trait locus 、 Genetics
摘要: ABSTRACT Using a combination of data from the BovineSNP50 BeadChip SNP array (Illumina, San Diego, CA) and EuroGenomics (Amsterdam, Netherlands) custom single nucleotide polymorphism (SNP) chip with pre-selected whole genome sequence data, we carried out an association study milking speed in 32,491 French Holstein dairy cows. Milking was measured by score given farmer. Phenotypes were yield deviations as obtained evaluation system. They analyzed linear mixed model for studies. We identified on 22 chromosomes significantly associated speed. As clinical mastitis somatic cell have unfavorable genetic correlation speed, tested whether most significant these also or score. Nine hundred seventy-one genome-wide Of these, 86 198 The signals observed 7, 8, 10, 14, 18. signal located chromosome 14 ( ZFAT gene). Eleven novel quantitative trait loci (QTL) 11, 18, 25, 26. Twelve candidate mapped directly within genes. 10 QTL lead SNP, which genes HMHA1 , POLR2E GNB5 KLHL29 KCNB2 CEACAM18 CCL24 LHPP . Limited pleiotropy between mastitis.
journalofdairyscience.org 参考文章(47)
Mekki Boussaha, Diane Esquerré, Johanna Barbieri, Anis Djari, Alain Pinton, Rabia Letaief, Gérald Salin, Frédéric Escudié, Alain Roulet, Sébastien Fritz, Franck Samson, Cécile Grohs, Maria Bernard, Christophe Klopp, Didier Boichard, Dominique Rocha, Genome-Wide Study of Structural Variants in Bovine Holstein, Montbéliarde and Normande Dairy Breeds PLOS ONE. ,vol. 10, pp. e0135931- 21 ,(2015) , 10.1371/JOURNAL.PONE.0135931
Robert Kammerer, Tanja Popp, Bernhard B. Singer, Jörg Schlender, Wolfgang Zimmermann, Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution Gene. ,vol. 339, pp. 99- 109 ,(2004) , 10.1016/J.GENE.2004.06.023
LA Crompton, J France, CK Reynolds, JAN Mills, MD Hanigan, JL Ellis, A Bannink, BJ Bequette, J Dijkstra, None, An isotope dilution model for partitioning phenylalanine and tyrosine uptake by the mammary gland of lactating dairy cows Journal of Theoretical Biology. ,vol. 359, pp. 54- 60 ,(2014) , 10.1016/J.JTBI.2014.05.012
C. J. Wilde, C. H. Knight, C. V. P. Addey, D. R. Blatchford, M. Travers, C. N. Bennett, M. Peaker, Autocrine regulation of mammary cell differentiation Protoplasma. ,vol. 159, pp. 112- 117 ,(1990) , 10.1007/BF01322594
F. H. Dodd, F. K. Neave, 448. Machine milking rate and mastitis Journal of Dairy Research. ,vol. 18, pp. 240- 245 ,(1951) , 10.1017/S0022029900006117
Keiko Doi, Takahiro Fujimoto, Midori Koyanagi, Toshiyuki Tsunoda, Yoko Tanaka, Yasuhiro Yoshida, Yasuo Takashima, Masahide Kuroki, Takehiko Sasazuki, Senji Shirasawa, ZFAT is a critical molecule for cell survival in mouse embryonic fibroblasts. Cellular & Molecular Biology Letters. ,vol. 16, pp. 89- 100 ,(2011) , 10.2478/S11658-010-0041-1
G.R. Wiggans, L.L.M. Thornton, R.R. Neitzel, N. Gengler, Short communication: Genetic evaluation of milking speed for Brown Swiss dairy cattle in the United States. Journal of Dairy Science. ,vol. 90, pp. 1021- 1023 ,(2007) , 10.3168/JDS.S0022-0302(07)71587-4
S. Gäde, E. Stamer, J. Bennewitz, W. Junge, E. Kalm, Genetic parameters for serial, automatically recorded milkability and its relationship to udder health in dairy cattle. Animal. ,vol. 1, pp. 787- 796 ,(2007) , 10.1017/S1751731107000092
Kathleen A. Smoak, John A. Cidlowski, Mechanisms of glucocorticoid receptor signaling during inflammation Mechanisms of Ageing and Development. ,vol. 125, pp. 697- 706 ,(2004) , 10.1016/J.MAD.2004.06.010
Melvyn S. Soloff, Michael H. Wieder, Oxytocin receptors in rat involuting mammary gland Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire. ,vol. 61, pp. 631- 635 ,(1983) , 10.1139/O83-079