The Quantitative Relation between Platelet Count and Hemorrhage in Patients with Acute Leukemia
作者： Lawrence A. Gaydos , Emil J. Freireich , Nathan Mantel
DOI: 10.1056/NEJM196205032661802
关键词: Anticoagulant effect 、 Medicine 、 Immunology 、 In patient 、 Gastroenterology 、 Internal medicine 、 Bacterial polysaccharide 、 Leukemic Infiltration 、 Acute leukemia 、 Platelet 、 Major complication 、 Coagulation defects 、 General Medicine
摘要: HEMORRHAGE is a frequent and often major complication in patients with acute leukemia. In addition to thrombocytopenia its resulting coagulation defects disturbances of the hemostatic mechanism have been described such patients.1 These include qualitative platelet defects2 3 4 presence fibrinolytic system hypofibrinogenemia.5 , 6 Fever, which presumably due bacterial infection, has found be related bleeding leukemia.6 7 This may result from anticoagulant effect polysaccharide demonstrated vitro.8 Capillary damage lysins,9 anoxemia or leukemic infiltration postulated.10 Although any all these . . .
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