Mitotic catastrophe and endomitosis in tumour cells: An evolutionary key to a molecular solution

摘要: Following genotoxic insult, p53 mutated tumour cells undergo mitotic catastrophe. This is characterised by a switch from mitosis to the endocycle. The essential difference between and endocycle that in latter, DNA synthesis uncoupled cell division, which leads formation of endopolyploid cells. Recent data suggests return into also possible. Furthermore, our observations indicate particular type known as endomitosis may be involved this return. Here we review role somatic reduction polyploidy during development its postulated evolution meiosis. Finally, incorporate these evolutionary help interpret most recent system, for meiotic regulators, p39mos segregation genomes (somatic reduction)