Association of IGF‐1 gene rs2195239 polymorphism with the risk and clinical features of gastric cancer in a Chinese Han population

摘要: BACKGROUND Recently, a Japanese study investigated the relationship between insulin-like growth factor-1 (IGF-1) gene rs2195239 polymorphism and gastric cancer (GC) risk found did not relate with of GC. However, no Chinese studies have addressed this until now. Thus, aims were to demonstrate whether IGF-1 was linked clinical features GC in Han population. METHODS In order verify link risk, we recruited 361 cases 418 controls case-control study. The genotyping done by use custom-by-design 48-Plex SNP scan TM Kit. RESULTS This that decreased Stratified analyses suggested significant association shown females, non-smokers, non-drinkers, age <60 years groups for addition, correlated tumor size, stage, pathological types patients. CONCLUSION To sum up, shows is associated patients