Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer
作者： Jeroen Krijgsveld , Roland Eils , Sebastian M Dieter , Mark Kriegsmann , Claudia R Ball
关键词: Colorectal cancer 、 Cell subpopulations 、 Tumor Initiating Cells 、 Tumor initiating cell 、 Cancer cell 、 Cell 、 Cancer research 、 Treatment resistance 、 Metabolic state 、 Biology
摘要: Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell RNA-sequencing patient-derived CRC models to decipher distinct subpopulations based on their transcriptional profiles. Cell type-specific expression modules stem-like, transit amplifying-like, differentiated cells resemble differentiation states normal intestinal epithelial cells. Strikingly, identified differ in proliferative metabolic state. In summary, here show at resolution that identifies functional during TIC differentiation. Furthermore, signatures are linked patient prognosis. Targeting associated might unravel novel vulnerabilities human CRC.
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