Cytokines in Epithelial-Mesenchymal Transition: A New Insight Into Obstructive Nephropathy

摘要: Purpose: Tubulointerstitial fibrosis is the final common pathway to end stage renal disease. The pathophysiology of involves fibroblast proliferation, macrophage infiltration, elaboration cytokines and other proinflammatory mediators, an imbalance in extracellular matrix deposition degradation. Although exact origin activated fibroblasts remains uncertain, emerging evidence indicates that mature tubular epithelial cells are capable transforming into myofibroblasts under pathological conditions, a process called epithelial-mesenchymal transition.Materials Methods: We reviewed pertinent literature from January 1980 through June 2007 with regard contribution transition fibrogenesis.Results: Epithelial-mesenchymal orchestrated, highly regulated proceeds stepwise fashion appears contribute significantly progression chronic Several ...