A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.

摘要: Identification of the nature severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS+ in lung fatally infected patients expressed only known functional receptor, angiotensin-converting enzyme 2, and also a binding liver/lymph node–specific ICAM-3–grabbing non-integrin (CD209L). In this study, show SARS-infected express stem/progenitor cell markers CD34 Oct-4, do not cytokeratin or surfactant. These putative can be identified some non-SARS individuals by SARS-coronavirus ex vivo. Infection these may contribute to loss repair capacity leads failure as clinically observed.