Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action
作者： Sheryl S. Smith , Barry D. Waterhouse , John K. Chapin , Donald J. Woodward
DOI: 10.1016/0006-8993(87)90634-2
关键词: Sex steroid 、 Cerebellar Purkinje cell 、 Endocrinology 、 Anxiolytic 、 Excitatory Amino Acid Antagonists 、 Inhibitory postsynaptic potential 、 Glutamate receptor 、 Neuromodulation 、 Biology 、 Internal medicine 、 Pharmacology 、 Glutamic acid
摘要: In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit a model extrahypothalamic CNS area. Spontaneous discharge and responses single cerebellar Purkinje neurons to microiontophoretically applied gamma-aminobutyric acid (GABA) glutamate monitored before, during after either systemic injection, at physiologic doses, or local application steroid. By both means administration, significantly enhanced inhibitory cells GABA suppressed excitation within 3-10 min post-steroid. These results are consistent with anxiolytic actions
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