Evaluation of antihypertensive effect of l-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring

摘要: BACKGROUND Arterial hypertension is one of the most important cardiovascular risk factors, featuring unsatisfactory efficacy current therapies. The disease paradigm which assumes a crucial role endothelial phenotype in shaping state circulatory system has become increasingly dominant and dysfunction should be treated as avidly diseases other organs. valued anti-hypertensive therapies exert positive influence on endothelium due to their pleiotropic effects, but search for new effective strategies aimed at improving function underway. L-arginine trials are part this quest. few studies have brought inconclusive results. aim study was evaluate safety profile L- arginine during four weeks oral supplementation healthy subjects patients diagnosed with primary mild hypertension. MATERIAL/METHODS completed by 54 participants. Ambulatory blood pressure monitoring (ABPM) used allot either control group (19 subjects) or hypertensive treatment (35 patients). Later were randomized (2 4 g three times daily placebo. All participants underwent physical examination had all basic lab tests ABPM performed. RESULTS Blood (both systolic diastolic) showed statistically significant lowering after only subgroup 12 daily, stronger hypotensive effect observed day. CONCLUSIONS present findings demonstrate strong association between reduction.