Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric
作者： Edward R. Monteith , Pieter Mampuys , Louise Summerton , James H. Clark , Bert U. W. Maes
DOI: 10.1039/C9GC01537J
关键词: Sequence 、 Toolbox 、 Set (abstract data type) 、 Intensity (heat transfer) 、 Product (mathematics) 、 Process (engineering) 、 Metric (unit) 、 Data mining 、 Key (cryptography) 、 Computer science
摘要: … PMI is the key metric adopted by the process chemists in pharmaceutical industry to measure the sustainability of a manufacturing process and was chosen for its ease in generating, …
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york.ac.uk 参考文章(38)
David J. C. Constable, Alan D. Curzons, Virginia L. Cunningham, Metrics to ‘green’ chemistry—which are the best? Green Chemistry. ,vol. 4, pp. 521- 527 ,(2002) , 10.1039/B206169B
M. Gabriela T.C. Ribeiro, Adélio A.S.C. Machado, Greenness of chemical reactions – limitations of mass metrics Green Chemistry Letters and Reviews. ,vol. 6, pp. 1- 18 ,(2013) , 10.1080/17518253.2012.669798
Stephen D. Roughley, Allan M. Jordan, The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates Journal of Medicinal Chemistry. ,vol. 54, pp. 3451- 3479 ,(2011) , 10.1021/JM200187Y
Sean K. Hamilton, Doug E. Wilkinson, Gregory S. Hamilton, Yong-Qian Wu, Microwave-assisted synthesis of N,N'-diaryl cyanoguanidines. Organic Letters. ,vol. 7, pp. 2429- 2431 ,(2005) , 10.1021/OL050728Q
Catherine Levallet, Joanne Lerpiniere, Soo Y Ko, The HgCl2-promoted guanylation reaction: The scope and limitations Tetrahedron. ,vol. 53, pp. 5291- 5304 ,(1997) , 10.1016/S0040-4020(97)00193-2
Peter J. Dunn, The importance of Green Chemistry in Process Research and Development Chemical Society Reviews. ,vol. 41, pp. 1452- 1461 ,(2012) , 10.1039/C1CS15041C
Alan D. Curzons, David N. Mortimer, David J. C. Constable, Virginia L. Cunningham, So you think your process is green, how do you know?—Using principles of sustainability to determine what is green–a corporate perspective Green Chemistry. ,vol. 3, pp. 1- 6 ,(2001) , 10.1039/B007871I
S. Fletcher, The Mitsunobu reaction in the 21st century Organic chemistry frontiers. ,vol. 2, pp. 739- 752 ,(2015) , 10.1039/C5QO00016E
Fiona I. McGonagle, Helen F. Sneddon, Craig Jamieson, Allan J. B. Watson, Molar efficiency : a useful metric to gauge relative reaction efficiency in discovery medicinal chemistry ACS Sustainable Chemistry & Engineering. ,vol. 2, pp. 523- 532 ,(2014) , 10.1021/SC4004532
Concepción Jiménez-González, David J. C. Constable, Celia S. Ponder, Evaluating the “Greenness” of chemical processes and products in the pharmaceutical industry—a green metrics primer Chem. Soc. Rev.. ,vol. 41, pp. 1485- 1498 ,(2012) , 10.1039/C1CS15215G