Effects of Age and Parity on Mammary Gland Lesions and Progenitor Cells in the FVB/N-RC Mice
作者： Ahmed Raafat , Luigi Strizzi , Karim Lashin , Erika Ginsburg , David McCurdy
DOI: 10.1371/JOURNAL.PONE.0043624
关键词: Prolactin 、 Progenitor cell 、 Population 、 Pituitary gland 、 Endocrinology 、 Mammary gland 、 Pathology 、 Internal medicine 、 Biology 、 Uterus 、 Hormone 、 Fat pad 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: The FVB/N mouse strain is extensively used in the development of animal models for breast cancer research. Recently it has been reported that aging mice develop spontaneous mammary lesions and tumors accompanied with abnormalities pituitary glands. These observations have a great impact on human cancer. We developed population inbred (designated FVB/N-RC) genetically isolated 20 years. To study effects age parity glands FVB/N-RC mice, twenty-five nulliparous multiparous (3–4 pregnancies) females were euthanized at 16–22 months age. Examination did not reveal macroscopic evidence gland either aged-nulliparous or (0/25). However, histological analysis showed rare focal nodules squamous changes 2 aged mice. Mammary hyperplasia was detected 8% 71% aged-multiparous respectively. Epithelial contents serum levels triiodothyronine significantly higher experimental groups than 14-wk-old control Immuno-histochemical staining pars distalis no difference prolactin between Tissue transplant dilution studies effect and/or ability putative progenitor cells present among injected to repopulate cleared fat pad full outgrowth. This substrain suitable
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