Effects of doxepin on perception of laboratory-induced pain in man.

摘要: Beneficial effects have been observed in University of Washington Pain Clinic patients treated with tricyclic antidepressants, but such occur much earlier than predicted mood elevation. A laboratory investigation pain perception was employed to test the hypothesis that doxepin, a antidepressant, has analgesic properties. Healthy, normal volunteers were tested over 4-week period during which they repeatedly performed Sensory Decision Theory tasks while undergoing painful dental stimulation. Doxepin and placebo administered after baseline measurement for 4 weeks under double blind conditions. No significant changes due drug administration detection threshold or sensory sensitivity indices, response bias against reporting stimuli as changed dramatically subjects began ingesting capsules. This effect evident both groups, it maintained across repeated testing. These observations suggest instructions given when is profound on report.