Hypothalamic Mechanisms in Cachexia

摘要: The role of nutrition and balanced metabolism in normal growth, development, health maintenance is well known. Patients affected with either acute or chronic diseases often show disorders nutrient balance. In some cases, a devastating state malnutrition known as cachexia arises, brought about by synergistic combination dramatic decrease appetite an increase fat lean body mass. Other common features that are not required for the diagnosis include decreases voluntary movement, insulin resistance, anhedonia. This found number including cancer, cystic fibrosis, AIDS, rheumatoid arthritis, renal failure, Alzheimer's disease. severity these illnesses primary determining factor both quality life, eventual mortality. Indeed, mass retention AIDS patients has stronger association survival than any other current measure led to intense investigation proposal numerous hypotheses regarding its etiology. Most authors suggest cytokines released during inflammation malignancy act on central nervous system alter release function neurotransmitters, thereby altering metabolic rate. review will discuss salient human diseases, mechanisms whereby alters key brain regions produce stereotypical illness behavior.