Cloning and characterization of seizure-related gene, SEZ-6.

摘要: SEZ-6 is a brain-specific cDNA. Its expression increased by convulsant drug and it encodes membrane protein with five copies of short consensus repeat (SCR; complement C3b/C4b binding site) two repeated sequences which are partially similar to CUB domain (complement Clr/s-like repeat). In this study, we analyzed the gene product antibody raised against peptide. vitro translation immunoblot revealed that modified post-translationally expressed in cerebrum cerebellum. To analyze detail, searched for other types cDNA polymerase chain reaction. Two additional cDNAs were isolated sequence analysis showed one different C-terminal region secreted SCRs CUB-like domain.