Synthetic Pesticides Used in Agricultural Production Promote Genetic Instability and Metabolic Variability in Candida spp.
作者： Leszek Potocki , Aleksandra Baran , Bernadetta Oklejewicz , Ewa Szpyrka , Magdalena Podbielska
关键词: Pesticide 、 Candida glabrata 、 Food science 、 Candida tropicalis 、 Acetamiprid 、 Thiacloprid 、 Epoxiconazole 、 Candida albicans 、 Biology 、 Neonicotinoid
摘要: The effects of triazole fungicide Tango® (epoxiconazole) and two neonicotinoid insecticide formulations Mospilan® (acetamiprid) Calypso® (thiacloprid) were investigated in Candida albicans three non-albicans species pulcherrima, glabrata tropicalis to assess the range morphological, metabolic genetic changes after their exposure pesticides. Moreover, bioavailability pesticides, which gives us information about metabolization was assessed using gas chromatography-mass spectrophotometry (GC-MS). tested pesticides caused differences between cells same studied populations response ROS accumulation, level DNA damage, fatty acids (FAs) phospholipid profiles, change percentage unsaturated saturated FAs or ability biofilm. In addition, for first time, effect insecticides on profile colony during aging demonstrated. Our data suggest that widely used including insecticides, may increase cellular diversity population-known as clonal heterogeneity-and thus play an important role acquiring resistance antifungal agents.
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