Free radical mechanisms of aging processes under physiological conditions.

摘要: Free radical theory of aging predicts crucial role for free radicals produced by external factors (environmental contamination, irradiation, etc.) or pathological disorders (hereditary diseases infections) in the initiation aging. Does it mean that under hypothetical completely physiological conditions processes could be fully suppressed? To answer this question, we will consider possible mechanisms formation such state. There are two major mechanisms, which responsible radical-mediated damage a living organism: superoxide overproduction mitochondria and nonenzymatic lipid peroxidation. Superoxide causes inhibition nitric oxide bioavailability, one principal characteristics aging, while peroxidation, is already demonstrated at conditions, produces toxic isoprostanes. We suggest initiators damaging leading to state oxidizable components diet. The possibility supplementation nontoxic antioxidants calorie restriction discussed. Scheme demonstrating potential starting presented, discussed on grounds known literature data.