Control of regioselectivity in cyclization of azadiketones to 3-ketopiperidine systems: Synthesis and stereochemistry of 1,2,5- and 1,5,6-trimethylpiperid-3-ones
作者： G. T. Katvalyan , �. A. Mistryukov
DOI: 10.1007/BF00954286
关键词: Ketone 、 Organic chemistry 、 Regioselectivity 、 Vinyl halide 、 Selectivity 、 Stereochemistry 、 Chemistry 、 Halide
摘要: 1. Regioselective cyclization of 3-aza-1,5-dehydropiperid-3-ones is complete on replacement the less hindered carbonyl by vinyl halide grouping. 2. Hydrogenation 2,5- and 5,6-dimethyl-substituted 4,5-dehydropiperid-3-ones Pd-C gives saturated ketones cis series with a high degree selectivity.
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sci-hub.se 参考文章(1)
E.A. Mistryukov, G.N. Smirnova, Conformational analysis of 4-ketopiperidines Tetrahedron. ,vol. 27, pp. 375- 377 ,(1971) , 10.1016/S0040-4020(01)90707-0