Inclusion bodies and their relationship to viruses

摘要: The term virus is not easily defined if it taken to include free-living nonpathogenic organisms of the types described by Barnard (1935) and Laidlaw Elford (1936) which, while very small size, can nevertheless be readily grown on artificial media. If, however, pathogenic saprophytic viruses only are considered, as agents exceeding 200 mμ in multiplication which dependent an intracellular existence. If then obligatory agents, perhaps surprising that their growth often, though invariably, associated with certain abnormal appearances within cell. Such may conceivably arise three ways: a) active either cytoplasm or nucleoplasm result formation masses colonies minute organisms; b) cell so stimulated attempts fence off its borders, c) without themselves being visible, cause great a derangement structure give rise That one other these processes often causes changes shown discovery number diseases cells containing what have been called “inclusion bodies” “inclusions”. These terms somewhat unsatisfactory since they imply something has included cell; addition apt lead ambiguity since, long before association action viruses, were used cytologists describe structures, such mitochondria Golgi apparatus (1. c), well normal secretory products metabolism. “virus body” also sometimes employed many ways preferable, provided body made up elements. In plant pathology “x usually applied produced general grounds less open objection than body”, “inclusion” body”: now extensively easy discontinue use.