Albuminuria and Microalbuminuria as Predictors of Cognitive Performance in a General Population: An 11-Year Follow-Up Study

摘要: Microalbuminuria, defined as urine albumin-to-creatinine ratio (UACR)>3.0 mg/mmol and ≤ 30 mg/mmol, is an early marker of endothelial damage the renal glomeruli. Recent research suggests association among microalbuminuria, albuminuria (UACR > 3.0 mg/mmol), cognitive impairment. Previous studies on albuminuria, cognition in middle-aged have not provided repeated testing at different time-points. We hypothesized that (micro- plus macroalbuminuria) microalbuminuria would predict decline independently previously reported risk factors for decline, including cardiovascular factors. In addition, we UACR levels even below cut-off might be associated with functioning. These hypotheses were tested Finnish nationwide, population-based Health 2000 Survey (n = 5,921, mean age 52.6, 55.0% women), its follow-up, 2011 (n = 3,687, baseline 49.3, 55.6% women). Linear regression analysis was used to determine associations between measures performance. Cognitive functions assessed verbal fluency, word-list learning, delayed recall (at follow-up), simple visual choice reaction time tests only). Here, show micro- macroalbuminuria poorer learning a slower baseline, steeper during 11 years after multivariate adjustments. Also, higher continuous consistently fluency microalbuminuria. results suggest value evaluating decline.