Influenza vaccination in pediatric age

摘要: Influenza is a very common disease among infants and young children, with considerable clinical socioeconomic impact [1]. To reduce the direct indirect effects of pediatric influenza virus infection, vaccination recommended worldwide for children considered at risk due to severe underlying disease. In healthy only in small number countries, although guidelines vary regarding minimum age [2]. USA universal all groups recommended, including until 17 years age. UK, group 4-17 years, program has been activated recently. Finally, Canada other European countries which health autorithies recommend vaccine also population, school-age adolescents are excluded. However, large authorities still reluctant include their national programs The reasons this reluctance fact that protection offered by currently available vaccines poor, particularly younger children. Regarding immunogenicity, quite similar elderly, who, because senescence immune system, respond poorly stimulation both these subjects, innate adaptive system functioning. particular, B-cells, essential antibody production memory, have limited responses. increase response inactivated vaccines, measures tested found be effective adults elderly studied [3]. use adjuvanted intradermal (ID) injection, administration an increased dose antigens live attenuated (LAIV) evaluated controlled trials, good results Moreover, possibility protecting through quadrivalent (QIV) None definitively accepted fear adverse events some instances data immunogenicity and/or efficacy lacking or not completely convincing. preliminary interesting cases suggest must further developed if problem poor solved.