A clinical study of the relationship between silicone breast implants and connective tissue disease.

摘要: OBJECTIVE: This study was a blinded, concurrent assessment of historical cohort derived from provincial registry (1978 to 1986) breast implant recipients (cosmetic, not reconstructive) and controls (other cosmetic surgery) test the hypothesis that connective tissue disease (CTD) is increased in recipients. METHODS: Women who underwent or other surgery during interval 1978 1986 were contacted confidentially by Alberta Health asked participate study. Those willing completed an extensive questionnaire supplied blood sample, subsequent which all surgical records reviewed confirm type(s) surgery(ies). All participants with any suggestion rheumatic assessed blindly rheumatologist for CTD. RESULTS: One thousand five hundred seventy-six recruited, including 1112 had received silicone gel-filled implants (> 13,500 person yrs exposure). Seven twenty-six recruited. Prevalence rates adjusted sex age rheumatoid arthritis, systemic lupus erythematosus, scleroderma, Sjogren's syndrome (the principal targeted conditions) consistent published reports Caucasian women. While self-reported significantly greater symptoms than controls, post-surgical diagnoses conditions did indicate incidence typical atypical CONCLUSION: The results do support induce promote