Exceptionally Mild Palladium(II)-Catalyzed Dehydrogenative C–H/C–H Arylation of Indolines at the C-7 Position under Air

作者: Lin-Yu Jiao , Polina Smirnov , Martin Oestreich

DOI: 10.1021/OL503035Z

关键词: Medicinal chemistryImproved methodCatalysisOrganic chemistryPalladiumChemistryUrea

摘要: An improved method for the dehydrogenative C–H/C–H cross-coupling at C-7 position of indolines containing a urea as directing group is reported. The new protocol rare example an aerobic palladium(II)-catalyzed cross coupling (CDC) reaction that proceeds low temperature. use either Cu(OAc)2 in open flask or dioxygen (balloon) 50 °C tolerates not substituted C-2 and C-3, thereby extending scope previous suffers from indoline-to-indole oxidation.

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