作者: Lin-Yu Jiao , Polina Smirnov , Martin Oestreich
DOI: 10.1021/OL503035Z
关键词: Medicinal chemistry 、 Improved method 、 Catalysis 、 Organic chemistry 、 Palladium 、 Chemistry 、 Urea
摘要: An improved method for the dehydrogenative C–H/C–H cross-coupling at C-7 position of indolines containing a urea as directing group is reported. The new protocol rare example an aerobic palladium(II)-catalyzed cross coupling (CDC) reaction that proceeds low temperature. use either Cu(OAc)2 in open flask or dioxygen (balloon) 50 °C tolerates not substituted C-2 and C-3, thereby extending scope previous suffers from indoline-to-indole oxidation.