Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors
作者： Giovanni Palombi , Marco Farina , Jean-Philippe Rocher , Stefania Gagliardi , Emmanuel Le Poul
DOI:
关键词: Metabotropic glutamate receptor 、 Allosteric regulation 、 Peripheral nervous system 、 Neuroscience 、 Pharmacology 、 Metabotropic glutamate receptor 5 、 Cognitive decline 、 Schizophrenia 、 Chemistry 、 Metabotropic glutamate receptor 2 、 Heterocyclic derivatives
摘要: The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 defined in the description. Invention useful for treating central or peripheral nervous system disorders other affected by neuromodulatory effect mGluR5 positive allosteric modulators such as cognitive decline also treat both negative symptoms schizophrenia.
lens.org参考文章(19)
Ernest Ludwig Eliel, Samuel H. Wilen, Lewis N. Mander, Stereochemistry of Organic Compounds ,(1962)
Shin Hayao, Wallace Glenn, 5-phenyl (or 5-phenylalkyl)-2-(omega-(4-phenyl-1-piperazinyl)alkyl)tetrazoles ,(1967)
Giovanni Palombi, Jean-Philippe Rocher, Stefania Gagliardi, Novel Tetrazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate ,(2005)
Alain Durand, Eric Diehl, Process for updating a revocation list of noncompliant keys, appliances or modules in a secure system for broadcasting content ,(2002)
Giovanni Palombi, Jean-Philippe Rocher, Stefania Gagliardi, Piergiuliano Bugada, Carbamate derivatives as positive allosteric modulators of metabotropic glutamate receptors ,(2006)
Nicholas D. Smith, Dehua Huang, Nicholas D. P. Cosford, Essa Hsinyi Hu, 4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5 ,(2004)
Peter G. M. Wuts, Theodora W. Greene, Protective groups in organic synthesis ,(1981)
Pietro Mangiaracina, Mwangi W. Mutahi, John J. Piwinski, Robert G. Aslanian, Michael Y. Berlin, Wing C. Tom, Neng-Yang Shih, Kevin D. McCormick, Christopher W. Boyce, Stuart B. Rosenblum, Pauline C. Ting, Novel non-imidazole compounds ,(2001)
Anne-Sophie Bessis, Jean-Philippe Rocher, Beatrice Bonnet, Mark Epping-Jordan, Emmanuel Le Poul, Allosteric modulators of metabotropic glutamate receptors ,(2004)
Dario Braga, Fabrizia Grepioni, Making crystals from crystals: a green route to crystal engineering and polymorphism Chemical Communications. pp. 3635- 3645 ,(2005) , 10.1039/B504668H