Diagnosis and treatment of autoimmune hepatitis at age 65 and older.
作者： C. Verslype , C. George , E. Buchel , F. Nevens , W. van Steenbergen
DOI: 10.1111/J.1365-2036.2005.02403.X
关键词: Azathioprine 、 Internal medicine 、 Autoimmune hepatitis 、 Gastroenterology 、 Immunology 、 Incidence (epidemiology) 、 Methylprednisolone 、 Hepatitis 、 Cirrhosis 、 Biopsy 、 Medicine 、 Antibody
摘要: Summary Aim: To study features in older patients with autoimmune hepatitis, as this was considered mainly a disease of young females. Methods: Analysis 28 diagnosed at age ≥65 years compared 84 younger patients. Results: The incidence similar all decades. ratio M:F 1 : 3 (≥65 years) vs. 1 : 2 ( 1/40 50%, anti-liver kidney microsomes (anti-LKM) proved always negative. Histology showed acute necrotizing hepatitis 19%, severe interphase 15%, chronic plasmo-lymphocytic infiltrate 30%, cirrhosis 29% (with active inflammation one-third); biopsy refused 11%. elderly responded very well to low doses methylprednisolone (≤8 mg) and azathioprine (1 mg/kg). This schedule obviates side-effects such infections seen higher dosages. Conclusion: Autoimmune has be also looked for the hepatitis. steroid therapy should individualized but kept dose.
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