Assessing the performance of tissue-engineered urological implants

摘要: Abstract Regenerative medicine and tissue engineering technologies are rapidly advancing with potentially broad clinical applications, including those in the field of urology. Although all structures lower urinary tract (ureters, bladder, sphincter, urethra) would undoubtedly benefit from utilization technologies, this report will focus on applications bladder. In regard, results both preclinical investigations support use engineered bladder constructs/implants for treatment end-stage disease. Despite great progress, further optimization groundbreaking technology require a more complete characterization understanding regeneration vitro vivo. The complexity normal structure physiology, turn, requires rigorous examination ’biomimetics' to ensure that they do indeed provide required structure, physiology function. chapter we outline an algorithm evaluation function be useful such physiological attributes regenerating bladders. Briefly, propose multidisciplinary ’vertical approach’ assesses characteristics function/phenotype at genetic, cellular, molecular, whole animal level. Appropriate methods instruments already available end, describe rationale comparison engineered/regenerating bladders native