Stereotactic radiosurgery for brain metastasis from renal cell carcinoma

摘要: BACKGROUND The authors evaluated results after stereotactic radiosurgery (SR) for brain metastases from renal cell carcinoma (RCC) and identified factors associated with improved survival tumor control. METHODS The reviewed the management a total of 52 RCC in 35 consecutive patients who underwent during 9-year interval. Twenty-eight also whole radiation therapy (WBRT). The mean volume was 2.4 mL (range, 0.1-14.1 mL). dose delivered to margin 17 gray (Gy) 13-20 Gy). Univariate multivariate testing performed determine significant prognostic factors. RESULTS The median 11 months SR 14 diagnosis. Only 2 (8%) died progression irradiated tumor. Age < 55 years, lack active systemic disease, use chemotherapy and/or immunotherapy were favorable testing. Post-SR imaging 26 (39 tumors). local control rate 39 treated tumors imaged 90% (tumor disappearance, 21%; regression, 44%; stable 26%). Local recurrence developed 3 (4 lesions) remote disease 12 patients. No patient new focal neurologic deficit due SR. Patients classified into two groups: without WBRT. addition WBRT did not improve survival. Distant failure occurred similarly both groups (46% vs. 50%). combined may contribute control, but prevent development tumors. CONCLUSIONS SR metastasis majority few complications. Early detection treatment provides extended quality Cancer 1998;83:344-353. © 1998 American Society.