MicroRNA-92a Upholds Bmp Signaling by Targeting noggin3 during Pharyngeal Cartilage Formation
作者： Guozhu Ning , Xiuli Liu , Miaomiao Dai , Anming Meng , Qiang Wang
DOI: 10.1016/J.DEVCEL.2012.12.016
关键词: Chondrogenesis 、 Cartilage 、 Cell biology 、 Cellular differentiation 、 Cartilage metabolism 、 microRNA 、 Biology 、 Progenitor cell 、 Ectopic expression 、 Anatomy 、 Signal transduction
摘要: Craniofacial malformations are common structural birth defects and usually associate with abnormal development of pharyngeal arches. Although some microRNAs have been found to be implicated in chondrogenesis in vitro, few shown essential for cartilage bone at the whole organism level. In this study, we report that mir92a is highly enriched chondrogenic progenitors its inactivation results loss elements due poor proliferation, impaired differentiation, unsustainable survival progenitors. The Bmp antagonist gene noggin3 (nog3) a direct target mir92a. Inactivation stabilizes nog3 mRNA, leading repression signaling behaviors contrast, ectopic expression duplex decreases mRNA levels and, as result, derepresses promotes cell apoptosis. Therefore, acts maintain activity during formation by targeting nog3.
core.ac.uk
sci-hub.se 参考文章(72)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Anne K. Knecht, Marianne Bronner-Fraser, Induction of the neural crest: a multigene process. Nature Reviews Genetics. ,vol. 3, pp. 453- 461 ,(2002) , 10.1038/NRG819
Masatoshi Shigoka, Akihiko Tsuchida, Takaaki Matsudo, Yuichi Nagakawa, Hitoshi Saito, Yoshiaki Suzuki, Tatsuya Aoki, Yoshiki Murakami, Hidenori Toyoda, Takashi Kumada, Ralf Bartenschlager, Nobuyuki Kato, Masanori Ikeda, Tomoki Takashina, Masami Tanaka, Rieko Suzuki, Kosuke Oikawa, Masakatsu Takanashi, Masahiko Kuroda, Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development Pathology International. ,vol. 60, pp. 351- 357 ,(2010) , 10.1111/J.1440-1827.2010.02526.X
J.M. Hurle, M.A. Ros, Y. Ganan, D. Macias, M.E. Piedra, T.K. Sampath, Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development Development. ,vol. 124, pp. 1109- 1117 ,(1997) , 10.1242/DEV.124.6.1109
Gary Ruvkun, Brenda J. Reinhart, Frank J. Slack, Michael Basson, Amy E. Pasquinelli, Jill C. Bettinger, Ann E. Rougvie, H. Robert Horvitz, The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature. ,vol. 403, pp. 901- 906 ,(2000) , 10.1038/35002607
Katiucia Batista Silva Paiva, Maria das Graças Silva-Valenzuela, Silvia Maria Gomes Massironi, Gui Mi Ko, Filipe Modolo Siqueira, Fabio Daumas Nunes, Differential Shh, Bmp and Wnt gene expressions during craniofacial development in mice Acta Histochemica. ,vol. 112, pp. 508- 517 ,(2010) , 10.1016/J.ACTHIS.2009.05.007
T. Kobayashi, J. Lu, B. S. Cobb, S. J. Rodda, A. P. McMahon, E. Schipani, M. Merkenschlager, H. M. Kronenberg, Dicer-dependent pathways regulate chondrocyte proliferation and differentiation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 1949- 1954 ,(2008) , 10.1073/PNAS.0707900105
Debra L. Ellies, Robert M. Langille, C. Cristofre Martin, Marie-Andrée Akimenko, Marc Ekker, Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos Mechanisms of Development. ,vol. 61, pp. 23- 36 ,(1997) , 10.1016/S0925-4773(96)00616-8
Thomas S. Vihtelic, Y. Yamamoto, M.T. Sweeney, W.R. Jeffery, David R. Hyde, Arrested differentiation and epithelial cell degeneration in zebrafish lens mutants. Developmental Dynamics. ,vol. 222, pp. 625- 636 ,(2001) , 10.1002/DVDY.1217
Kathryn A. O'Donnell, Erik A. Wentzel, Karen I. Zeller, Chi V. Dang, Joshua T. Mendell, c-Myc-regulated microRNAs modulate E2F1 expression. Nature. ,vol. 435, pp. 839- 843 ,(2005) , 10.1038/NATURE03677