Arginine methylation of G3BP1 in response to Wnt3a regulates β-catenin mRNA
作者： R. K. Bikkavilli , C. C. Malbon
DOI: 10.1242/JCS.084046
关键词: Methylation 、 WNT3A 、 Dishevelled 、 Frizzled 、 Wnt signaling pathway 、 Beta-catenin 、 Signal transduction 、 Molecular biology 、 Biology 、 Wnt3A Protein
摘要: Wnt/β-catenin signaling is essential for normal mammalian development. Wnt3a activates the pathway through stabilization of β-catenin; a process in which phosphoprotein Dishevelled figures prominently. Protein arginine methylation complexes containing was investigated. Mass spectrometry prominent arginine-methylated, Dishevelled-associated protein identified Ras GTPase activating protein-binding 1 G3BP1. Stimulation totipotent mouse embryonic F9 cells with provoked increased We show that G3BP1 novel Ctnnb1 mRNA binding protein. Methylation constitutes molecular switch regulates response to Wnt3a. Thus, targets acts as regulator mRNA.
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