Advances in musculoskeletal tissue engineering: moving towards therapy.

作者: Carlo Alberto Rossi , Michela Pozzobon , Paolo De Coppi

DOI: 10.4161/ORG.6.3.12419

关键词: DenervationSurgeryRegeneration (biology)Skeletal muscleMyocyteBioinformaticsBiocompatible materialTissue engineeringMedicineStem cellParacrine signalling

摘要: Skeletal muscle can self-repair, but is unable to restore significant tissue loss, as consequence of trauma, congenital defects, tumor ablation or denervation. Intramuscular injection autologous allogenic derived myogenic cells (namely satellite and myoblasts) did not lead efficient regeneration because poor cell retention survival, well immunorejection. In the last decade, engineering looked at overcoming these problems by investigating alternative treatment options, i.e., suspension precursors in temporary matrix, formed biodegradable biocompatible materials. This approach allows engineer custom architectured preconditioned implants, locally deliver paracrine factors.This article reviews current potential strategies for repair damaged suggests some innovative approaches translation clinical setting.

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