Total Synthesis of (±)‐Lysergic Acid by an Intramolecular Imino‐Diels‐Alder Reaction. Preliminary communication
作者： Wolfgang Oppolzer , Eric Francotte , Kurt Bättig
关键词: Stereochemistry 、 Diels–Alder reaction 、 Intramolecular force 、 Chemistry 、 Total synthesis 、 Lysergic acid 、 Cycloaddition 、 Diene 、 Thermal decomposition
摘要: (±)-Lysergic acid (1) has been synthesized from 4-hydroxymethyl-1-tosylindole (2) by a sequence of 9 steps. The crucial thermolysis 10 involves the in situ-generation transient diene III which undergoes an intramolecular cycloaddition to C, N-double bond at 200° and low stationary concentration III.
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