Myostatin knockout in mice increases myogenesis and decreases adipogenesis.

作者: Ji Lin , Heather B. Arnold , Mary Anne Della-Fera , Michael J. Azain , Diane L. Hartzell

DOI: 10.1006/BBRC.2002.6500

关键词: Enhancer bindingLeptinMyogenesisKnockout mouseEndocrinologyAdipogenesisMyostatinAdipose tissueInternal medicineBiologyWild type

摘要: … Myostatin gene knockout may cause a switch between myogenesis and adipogenesis. Male and female wild type (WT) and Myostatin knockout … development in Myostatin knockout mice …

参考文章(12)
Luc Grobet, Dominique Poncelet, Luis José Royo, Benoit Brouwers, Dimitri Pirottin, Charles Michaux, François Ménissier, Marta Zanotti, Susana Dunner, Michel Georges, Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle Mammalian Genome. ,vol. 9, pp. 210- 213 ,(1998) , 10.1007/S003359900727
A. C. McPherron, S.-J. Lee, Double muscling in cattle due to mutations in the myostatin gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 12457- 12461 ,(1997) , 10.1073/PNAS.94.23.12457
E. W. Hartsook, T. V. Hershberger, A Simplified Method for Sampling Small Animal Carcasses for Analyses. Experimental Biology and Medicine. ,vol. 113, pp. 973- 977 ,(1963) , 10.3181/00379727-113-28548
M. J. Azain, T. J. Roberts, R. J. Martin, T. R. Kasser, Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats. Journal of Animal Science. ,vol. 73, pp. 1019- 1029 ,(1995) , 10.2527/1995.7341019X
H. C. Freetly, J. A. Nienaber, K. A. Leymaster, T. G. Jenkins, Relationships among heat production, body weight, and age in Suffolk and Texel ewes. Journal of Animal Science. ,vol. 73, pp. 1030- 1037 ,(1995) , 10.2527/1995.7341030X
Mark Westhusin, From mighty mice to mighty cows. Nature Genetics. ,vol. 17, pp. 4- 5 ,(1997) , 10.1038/NG0997-4
Luc Grobet, Luis José Royo Martin, Dominique Poncelet, Dimitri Pirottin, Benoit Brouwers, Juliette Riquet, Andreina Schoeberlein, Susana Dunner, François Ménissier, Julio Massabanda, Ruedi Fries, Roger Hanset, Michel Georges, A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nature Genetics. ,vol. 17, pp. 71- 74 ,(1997) , 10.1038/NG0997-71
Alexandra C. McPherron, Ann M. Lawler, Se-Jin Lee, Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. ,vol. 387, pp. 83- 90 ,(1997) , 10.1038/387083A0
J.M.W Slack, Growth control: Action mouse Current Biology. ,vol. 7, pp. R467- R469 ,(1997) , 10.1016/S0960-9822(06)00238-7