Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus Aspergillus sp. TJ23.
作者： Yuben Qiao , Kun Tu , Wenya Feng , Junjun Liu , Qianqian Xu
关键词: Bioassay 、 Polyketide 、 Strain (chemistry) 、 In vitro 、 Stereochemistry 、 Circular dichroism 、 Biological activity 、 Chemistry 、 Ergosterol 、 Aspergillus
摘要: Eight secondary metabolites, including a new polyketide, named asperetide (1) and prenylxanthone derivative, called asperanthone (4), six known compounds, (S)-3-butyl-7-methoxyphthalide (2), ruguloxanthone C (3), tajixanthone hydrate (5), methanoate (6), salimyxin B (7), ergosterol (8), were isolated identified from the medicinal plant-derived fungus, Aspergillus sp. TJ23. The structures their absolute configurations elucidated via multiple methods, 1D- 2D-NMR, HR-ESI-MS, UV, IR, electronic circular dichroism (ECD) calculations. All of isolates characterized strain for first time. in vitro bioassay showed that compounds 3-5 8 exerted inhibitory activities against five cancer cell lines (B16, MDA-MB-231, 4T1, HepG2, LLC) with IC50 values ranging 5.13 to 36.8 μm.
sci-hub.se 参考文章(20)
Shuangshuang Xie, Ye Wu, Yuben Qiao, Yi Guo, Jianping Wang, Zhengxi Hu, Qing Zhang, Xiaonian Li, Jinfeng Huang, Qun Zhou, Zengwei Luo, Junjun Liu, Hucheng Zhu, Yongbo Xue, Yonghui Zhang, Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A Journal of Natural Products. ,vol. 81, pp. 1311- 1320 ,(2018) , 10.1021/ACS.JNATPROD.7B00889
Yuben Qiao, Xiaotian Zhang, Yan He, Weiguang Sun, Wenya Feng, Junjun Liu, Zhengxi Hu, Qianqian Xu, Hucheng Zhu, Jinwen Zhang, Zengwei Luo, Jianping Wang, Yongbo Xue, Yonghui Zhang, Aspermerodione, a novel fungal metabolite with an unusual 2,6-dioxabicyclo[2.2.1]heptane skeleton, as an inhibitor of penicillin-binding protein 2a. Scientific Reports. ,vol. 8, pp. 5454- 5454 ,(2018) , 10.1038/S41598-018-23817-1
Gary Strobel, Bryn Daisy, Uvidelio Castillo, James Harper, Natural products from endophytic microorganisms. Journal of Natural Products. ,vol. 67, pp. 257- 268 ,(2004) , 10.1021/NP030397V
Panawan Moosophon, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Kasem Soytong, Prenylxanthones and a bicyclo[3.3.1]nona-2,6-diene derivative from the fungus Emericella rugulosa. Journal of Natural Products. ,vol. 72, pp. 1442- 1446 ,(2009) , 10.1021/NP800805F
Stephan Felder, Stefan Kehraus, Edith Neu, Gabriele Bierbaum, Till F. Schäberle, Gabriele M. König, Salimyxins and Enhygrolides: Antibiotic, Sponge‐Related Metabolites from the Obligate Marine Myxobacterium Enhygromyxa salina ChemBioChem. ,vol. 14, pp. 1363- 1371 ,(2013) , 10.1002/CBIC.201300268
John Knight, The Claisen Rearrangement: Methods and Applications . Edited by Martin Hiersemann and Udo Nubbemeyer . Wiley-VCH Verlag GmbH and Co. KGaA : Weinheim . 591 pp. £155. ISBN 978-3-527-30825-5 . Organic Process Research & Development. ,vol. 12, pp. 1016- 1016 ,(2008) , 10.1021/OP800174S
Jittra Piapukiew, Ek Sangvichien, Songchan Puthong, Amorn Petsom, Surachai Pornpakakul, Jatupol Liangsakul, Nattaya Ngamrojanavanich, Sophon Roengsumran, Prakitsin Sihanonth, Cytotoxic activity of four xanthones from Emericella variecolor, an endophytic fungus isolated from Croton oblongifolius. Archives of Pharmacal Research. ,vol. 29, pp. 140- 144 ,(2006) , 10.1007/BF02974275
Mikko J. Vainio, Mark S. Johnson, Generating conformer ensembles using a multiobjective genetic algorithm. Journal of Chemical Information and Modeling. ,vol. 47, pp. 2462- 2474 ,(2007) , 10.1021/CI6005646
James F. Sanchez, Amber D. Somoza, Nancy P. Keller, Clay C. C. Wang, Advances in Aspergillus secondary metabolite research in the post-genomic era Natural Product Reports. ,vol. 29, pp. 351- 371 ,(2012) , 10.1039/C2NP00084A
Vilailak Prachyawarakorn, Chulabhorn Mahidol, Sanya Sureram, Suwannee Sangpetsiripan, Suthep Wiyakrutta, Somsak Ruchirawat, Prasat Kittakoop, Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales. Planta Medica. ,vol. 74, pp. 69- 72 ,(2008) , 10.1055/S-2007-993783