N-terminal pro-B-type natriuretic peptide as an indicator of disease severity in a heterogeneous group of patients with chronic precapillary pulmonary hypertension.

摘要: N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) is well established as a predictor of prognosis in patients with left ventricular dysfunction. Although similar prognostic significance has been suggested 1 study right failure and idiopathic pulmonary arterial hypertension, NT-pro-BNP not assessed marker disease severity more heterogenous group chronic precapillary hypertension (PH). Hence, this plasma other clinical variables 61 consecutively recruited various forms PH. Right-sided cardiac catheterization cardiopulmonary exercise testing were performed at baseline, the was investigated mean follow-up 25 months. Compared age-matched controls (n = 10), significantly greater those 16), PH associated diseases 26), thromboembolic 19) correlated hemodynamic functional capacity. In 17 medically treated patients, significant decrease levels improved hemodynamics. During follow-up, 15 died from causes. Baseline an independent mortality. Kaplan-Meier survival analysis according to median value (168 pmol/L) demonstrated higher mortality rate supramedian values than low (p 0.010). conclusion, these findings suggest that PH, can be used determine independently long-term