Rapid improvement of acute pulmonary edema with sublingual captopril.
作者： Richard J Hamilton , Wallace A Carter , E John Gallagher , None
DOI: 10.1111/J.1553-2712.1996.TB03422.X
关键词: Regimen 、 Anesthesia 、 Captopril 、 Respiratory failure 、 Randomized controlled trial 、 Medicine 、 Placebo 、 Mechanical ventilation 、 Furosemide 、 Pulmonary edema
摘要: Objective: To test the hypothesis that sublingual captopril produces a more rapid improvement of acute pulmonary edema (APE) than does placebo, when added to standard regimen O2, nitrates, morphine, and furosemide. Methods: Prospective, randomized, double-blind, placebo-controlled clinical trial in an urban teaching hospital ED. Adults brought ED with APE were given or placebo sublingually Every 5 minutes distress score (APEX) was obtained. Results: Over first 40 treatment, mean APEXs significantly better for patients [p < 0. 001, F = 14. 5, one-way (repeated-measures) analysis variance (ANOVA)]. At 30 minutes, had APEX 43% (i. e., 57% initial distress); group current plus improved only 25% 75% distress; p 03, multiway ANOVA). In addition, there less respiratory failure necessitating mechanical ventilation (9%) vs (20%), which did not achieve significance (p 10, Fisher's exact test). Conclusion: APE, addition furosemide alone.
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